Study on Synergistic Effect of Dioctyl Sodium Sulfosuccinate, Sodium Starch Glycolate and Crospovidone on Drug Release Profile of Orodispersible Tablets of Rizatriptan Benzoate

Abstract

Orodispersible Tablets are expected to have disintegration rapidly within the mouth cavity. To overcome the problems of solid dosage forms and to facilitate the patients with easy swallowing tablets pharmaceutical companies have formulated Oral Disintegrating Tablets, which disintegrate in saliva, within few seconds. Rizatriptan Benzoate can be formulated as Orodispersible tablet successfully by using the wet granulation process. Crospovidone, SSG and DOSS were used in the varying concentrations during the formulation. Other excipients like Microcrystalline Cellulose, Sodium Stearyl Fumarate, Colloidal Silicon Dioxide (Aerosil), and aspartame were also used and IPA was used as the solvent in the wet granulation technique Nine different formulations were prepared. Formulation containing SSG in the intermediate concentration and Crospovidone in the higher concentration in presence of DOSS showed the least time for disintegration and highest amount of In-vitro drug release. DOSS helps to facilitate the dissolution rate of the dosage forms. Thus the Formulations containing DOSS along with the other Superdisintegrant help to increase the dissolution rate of the dosage forms.  Formulation containing highest concentration of SSG, lowest concentration of Crospovidone and without the use of DOSS showed the maximum Disintegration time compared and lowest dissolution rate. SSG in concentration greater than 8% shows gelling and viscosity producing effects which results increase in DT and decreased dissolution rate.