Effect of Variation of Concentration of Film Forming Polymer and Superdisintegrating Agent on Release Profile of Mouth Dissolving Film of Telmisartan

Abstract

Mouth dissolving films offer the extensive range of benefits and among them patient compliance and easiness for taking the drug without water are the superior one. For the formation of the mouth dissolving films different material can be used such as film forming polymer, superdisintegrants, saliva stimulating agents, surfactants or wetting agents, buffering agents, plasticizers etc. Combination of these agents at suitable concentration helps in the formation of mouth dissolving film of required quality. Role of the superdisintegrants is considered crucial. Higher concentration of superdisintegrant contributes for the better release profile whereas the lower concentration of superdisintegrant hinders the release pattern of drug from the mouth dissolving film. Similarly, Higher amount/concentration of polymer hinders the release pattern whereas the lower amount of the plasticizer enhance the release pattern of the drug  as the  higher concentration leads to the gel formation thus affecting the drug release.  Thus optimum formulation containing high concentration of super disintegrating agent and minimum concentration of the polymers for film formation shows the better outcome.