Recent Advances in Nanoparticle-Based Drug Delivery Systems

Abstract

Nanoparticle-based drug delivery systems (NDDS) have emerged as a revolutionary approach in pharmaceutical development, offering significant improvements in drug bioavailability, therapeutic efficacy, and patient compliance. This review provides an overview of recent advances in nanoparticle-based drug delivery systems, focusing on novel nanoparticle formulations, surface modifications for targeted drug delivery, and the mechanisms of controlled release. The article explores various types of nanoparticles, including polymeric nanoparticles, liposomes, lipid nanoparticles, dendrimers, nanogels, and hybrid materials, and their applications in diverse therapeutic areas such as cancer therapy, gene delivery, and vaccine development. A particular emphasis is placed on the advancements in surface modification techniques, such as PEGylation and antibody conjugation, which enhance targeting and minimize off-target effects. Additionally, the review discusses smart nanoparticles that respond to stimuli (e.g., pH, temperature, and light) for controlled and triggered release of drugs, as well as challenges related to toxicity, scalability, and regulatory approval. Furthermore, the article highlights the potential of nanoparticle-based systems in personalized medicine and their future prospects in treating complex diseases like cancer, neurological disorders, and genetic conditions. Despite challenges, such as the need for improved safety profiles and large-scale production techniques, the continued development of nanotechnology holds great promise for transforming drug delivery paradigms and advancing the field of medicine.