Planterosomal Gel designed by different Polyherbal Herbs: A Novel Method for Skin Healing

Main Article Content

Richa Mishra
Shalini Singh
Shrishti Mishra
Shubham Bhatt

Abstract

Skin healing is complex and involves a wide range of cellular and molecular interactions. Because they include a wide variety of bioactive components, traditional herbal treatments have long been acknowledged for their ability to aid in the healing of wounds. In this work, we present a unique method of creating a planterosomal gel to utilize the medicinal qualities of polyherbal plants. Plant extract-derived planterosomes provide a viable platform for improving herbal medicines’ bioavailability and therapeutic effectiveness. Our goal was to develop a formulation that would enable the targeted delivery of bioactive ingredients to the site of damage and prolonged release of those constituents by encasing a synergistic combination of polyherbal extracts inside a gel matrix. Medicinal plants that are well-known for their ability to cure wounds were extracted for the formulation process. These herbs include Centella Asiatica, Calendula officinalis, and Aloe vera. After that, a specific method was used to encapsulate these herbal extracts into planterosomes, maintaining their stability and bioactivity. The effective encapsulation of herbal extracts within the planterosomal framework, with a homogeneous particle size distribution and desired physicochemical characteristics, was validated by characterization tests. Moreover, investigations conducted in vitro showed sustained release kinetics, suggesting the possibility of long-lasting therapeutic benefits. Animal models with skin wounds were used in in vivo research to assess the planterosomal gel’s effectiveness. Improved collagen deposition, decreased inflammation, and increased re-epithelialization showed that the polyherbal planterosomal gel treatment greatly sped up the healing process as compared to control groups. Using a combination of controlled release and targeted administration methods, this formulation maximizes the benefits of many herbal constituents working together to provide a potentially effective treatment for a range of dermatological diseases and wound care applications. The therapeutic effectiveness and safety of this novel formulation in human patients should be investigated further.

Article Details

How to Cite
Planterosomal Gel designed by different Polyherbal Herbs: A Novel Method for Skin Healing. (2024). Journal of Drug Discovery and Health Sciences, 1(02), 62-68. http://jddhs.com/index.php/jddhs/article/view/18
Section
Review Article

How to Cite

Planterosomal Gel designed by different Polyherbal Herbs: A Novel Method for Skin Healing. (2024). Journal of Drug Discovery and Health Sciences, 1(02), 62-68. http://jddhs.com/index.php/jddhs/article/view/18