Planterosomal Gel designed by different Polyherbal Herbs: A Novel Method for Skin Healing

Abstract

Skin healing is complex and involves a wide range of cellular and molecular interactions. Because they include a wide variety of bioactive components, traditional herbal treatments have long been acknowledged for their ability to aid in the healing of wounds. In this work, we present a unique method of creating a planterosomal gel to utilize the medicinal qualities of polyherbal plants. Plant extract-derived planterosomes provide a viable platform for improving herbal medicines’ bioavailability and therapeutic effectiveness. Our goal was to develop a formulation that would enable the targeted delivery of bioactive ingredients to the site of damage and prolonged release of those constituents by encasing a synergistic combination of polyherbal extracts inside a gel matrix. Medicinal plants that are well-known for their ability to cure wounds were extracted for the formulation process. These herbs include Centella Asiatica, Calendula officinalis, and Aloe vera. After that, a specific method was used to encapsulate these herbal extracts into planterosomes, maintaining their stability and bioactivity. The effective encapsulation of herbal extracts within the planterosomal framework, with a homogeneous particle size distribution and desired physicochemical characteristics, was validated by characterization tests. Moreover, investigations conducted in vitro showed sustained release kinetics, suggesting the possibility of long-lasting therapeutic benefits. Animal models with skin wounds were used in in vivo research to assess the planterosomal gel’s effectiveness. Improved collagen deposition, decreased inflammation, and increased re-epithelialization showed that the polyherbal planterosomal gel treatment greatly sped up the healing process as compared to control groups. Using a combination of controlled release and targeted administration methods, this formulation maximizes the benefits of many herbal constituents working together to provide a potentially effective treatment for a range of dermatological diseases and wound care applications. The therapeutic effectiveness and safety of this novel formulation in human patients should be investigated further.