Evaluation of Antidiabetic Efficacy Herbal Ethanolic Extracts inAlloxan-Induced Diabetes Rats

Abstract

Diabetes is traditionally treated with the huge climber plant Bauhinia vahlii Wight & Arn. The evaluated of antidiabetic effect of Bauhinia vahlii ethanolic extracts leaves and stem at doses of 200 mg/kg and 400 mg/kg using an experimental model by alloxan-induced diabetes in albino rats. The acute toxicity tests revealed that the extracts were not harmful, as there were no deaths at the dosages 2000 mg/kg. The groups were divided into herbal extracts doses, standard drug Glibenclamide at 5 mg/kg, diabetic control group, and normal control group. Blood sugar concentrations were regular monitor and measured for 21st days, and the levels of glucose in the blood after fasting were measured on days 0, 7, 14, and 21st in each of the animal groups. The remarkable antidiabetic effects significant (????<0.001)  at dose of 400 mg/kg of Bauhinia vahlii leaves extract comparable to glibenclamide diabetes control. This beneficial effect is probably due to the existence of flavonoids and phenolic substances, which might enhance the release of insulin.